Disodium hydrogen phosphate dihydrate is a colorless orthorhombic crystal or white powder. Its relative density is d = 162.066. It is soluble in water, and its aqueous solution is alkaline. Upon heating to 95°C, it loses two molecules of water of crystallization, becoming anhydrous.
Ⅰ.Disodium hydrogen phosphate dihydrate Introduction：
Disodium hydrogen phosphate dihydrate is used as a boiler water softener, a weighting agent for tanning leather and fabrics, a flame retardant for wood and paper, and a glaze and welding flux. It is also used as a mordant in dyeing and as a stabilizer in hydrogen peroxide bleaching in the printing and dyeing industry. It is a raw material for manufacturing sodium pyrophosphate and other phosphates. Furthermore, it is a culture medium for monosodium glutamate, erythromycin, penicillin, streptomycin, and wastewater biochemical treatment products. It combines the uses of disodium hydrogen phosphate dodecahydrate with the ability to prevent clumping during transportation and storage.
Ⅱ.Disodium hydrogen phosphate dihydrate CAS 10028-24-7 Application:
1. Disodium hydrogen phosphate dihydrate in the food and nutrition field:
As a food additive, it is a multifunctional ingredient permitted by the national standard (GB 25568-2010), mainly acting as a quality improver, pH adjuster, nutritional supplement, emulsifier, stabilizer, and binder. It is widely used in the processing of various foods, such as:
(1) Dairy products: such as cheese, condensed milk, cream, concentrated milk, ice cream, and infant formula.
(2) Disodium hydrogen phosphate dihydrate in Grains and pasta: breakfast cereals and pasta.
(3) Others: pudding powder, isotonic beverages, vitamin capsules, etc.
2. Oral care products: It plays a key role as a buffer and mineralization promoter in toothpaste formulations, with typical applications:
(1) Stabilizing active ingredients: In toothpaste using calcium carbonate as an abrasive, it effectively stabilizes the content of soluble fluoride, ensuring the anti-cavity efficacy of the toothpaste within its shelf life.
(2) Promotes Tooth Repair: Studies have found that anhydrous toothpaste containing disodium hydrogen phosphate and micron-sized calcium carbonate has good mineralization properties and can be used to repair demineralized enamel and dentin.
3. Disodium hydrogen phosphate dihydrate (CAS 10028-24-7) in Industrial and Chemical Raw Materials
In industrial applications, it is widely used as a basic chemical:
(1)Water Treatment: Used as a boiler water softener.
(2) Textiles and Paper: Used as a fabric weighting agent, dyeing detergent, and stabilizer for hydrogen peroxide bleaching.
4. Others:
Used as a fire retardant for wood and paper and as a raw material for welding flux.
5. Chemical Synthesis:
Used as a basic raw material in the manufacture of other phosphate products such as sodium pyrophosphate and sodium hexametaphosphate.
6. Disodium hydrogen phosphate dihydrate in Core Pharmaceutical Excipients (Standard for Formulation)
(1) pH Buffers (Maximum Usage Scenarios)
Combined with sodium dihydrogen phosphate to form a phosphate buffer system (PBS), stabilizing the physiological pH range of 5.8–8.0:
Injectables: Infusions, sterile aqueous injections, monoclonal antibody/protein injections, preventing protein denaturation and active ingredient degradation due to acid-base fluctuations;
Eye drops, ophthalmic gels: Matching the pH of human tears, reducing eye irritation, and extending the shelf life of eye drops;
Oral solutions, syrups, suspensions: Neutralizing acidic APIs, inhibiting hydrolysis, and improving taste;
Lyophilized formulations: Lyophilization protects the buffer matrix, ensuring pH stability after reconstitution;
Topical formulations: pH adjustment for creams, lotions, and rinsing solutions.
(2) Osmotic/Isotonic Adjusters
Combined with sodium chloride to adjust the osmotic pressure of injections and dialysate, avoiding vascular irritation and cell hemolysis; used in peritoneal dialysis solutions and intravenous nutrition infusions.
(3) Stabilizers and Chelating Agents (Anti-Degradation):
These can chelate trace amounts of iron, copper, and heavy metal ions, inhibiting drug oxidation and discoloration; commonly used as preservatives and enhancers in antibiotic and vitamin injections.
(4) Solubilizers and Dispersants:
These improve the solubility of poorly soluble drugs; and prevent particle flocculation and sedimentation in oral suspensions and granules.
Ⅲ. Key performance advantages of Disodium hydrogen phosphate dihydrate
1. Versatile Functions: Disodium hydrogen phosphate dihydrate
Combines most of the uses of both the anhydrous and dodecahydrate forms, serving as a highly efficient buffer, complexing agent, and quality improver in the food, pharmaceutical, and chemical industries.
2. Good Physical Stability: Disodium hydrogen phosphate dihydrate
Compared to the common dodecahydrate, the dihydrate is less prone to clumping during transportation and storage, making it more convenient to use. Compared to the anhydrous form, it is more suitable for certain reactions requiring controlled crystal water.
Ⅳ.Market situation and prospects of Disodium hydrogen phosphate dihydrate
Looking at the overall market for disodium hydrogen phosphate, including disodium hydrogen phosphate dihydrate, the global size was approximately US$1.1 billion in 2024 and is projected to grow to US$1.65 billion by 2033, with a compound annual growth rate (CAGR) of approximately 4.6%. The market specifically targeting disodium hydrogen phosphate dihydrate (SPDD) is predicted to grow globally from US$200 million in 2022 to US$280 million in 2027, with a CAGR of 8-10%, higher than the overall category growth rate.
Ⅴ. Conclusion
Disodium hydrogen phosphate dihydrate is a basic chemical raw material with stable demand and some growth potential. Its market opportunities lie more in cultivating the high-value-added pharmaceutical and food sectors, and winning customers through consistent product quality.
