5-Sulfosalicylic acid dihydrate cas no 5965-83-3 is an important organic compound with wide applications in pharmaceuticals, chemical engineering, and analytical chemistry. It is essentially a product of salicylic acid through sulfonation. By introducing a sulfonic acid group (-SO₃H) onto the benzene ring, it retains some of the properties of salicylic acid while acquiring new chemical characteristics.
Ⅰ. 5-Sulfosalicylic acid dihydrate Introduction：
1. Melting point: Approximately 120℃; easily decomposes upon heating.
2. Possesses a bifunctional group of phenolic hydroxyl and sulfonic acid groups, exhibiting complexing, precipitating, and acidic properties.
3. Can form a stable purple-red complex with ferric ions, showing sensitive and stable color development.
4.Aqueous solutions are prone to oxidation and discoloration upon prolonged storage; must be stored in a sealed, light-protected container.
Ⅱ.5-Sulfosalicylic acid dihydrate cas no 5965-83-3 Application:
1. 5-Sulfosalicylic acid dihydrate is primarily used as a multifunctional auxiliary agent in cosmetics.
Its acidity, chelating properties, and hydrophilicity improve product performance and skin feel, rather than being a primary active ingredient.
Core Efficacy and Functions.
5-Sulfosalicylic acid dihydrate pH Adjuster and Buffer
Precisely regulates the pH of cosmetics, maintaining system stability and adapting to the skin’s slightly acidic environment.
Enhances product stability against ions and temperatures, extending shelf life.
Gentle Exfoliation and Oil Control
Weaker acidity than salicylic acid, less irritating, gently loosening dead skin cells.
Helps unclog pores, inhibits sebum secretion, improves blackheads and closed comedones, suitable for sensitive and oily/acne-prone skin.
Metal Ion Chelating Agent (Stabilizer)
Powerfully chelates metal ions such as iron and copper in products, preventing oxidation, discoloration, and deterioration, protecting active ingredients such as fragrances and vitamin C.
5-Sulfosalicylic acid dihydrate in Moisturizing and Skin Feel Improvement
Strong hydrophilicity and hygroscopic capacity enhance moisturizing power, making the texture lighter and non-sticky.
Astringent and Soothing: Shrinks pores, calms redness, and helps improve acne inflammation.
5-Sulfosalicylic acid dihydrate Common Product Types:
Toners/Serums: pH adjustment, stabilizes active ingredients, helps control oil and exfoliate.
Oil-Control/Acne-Fighting Lotions: Gently unclogs pores, anti-inflammatory and soothing, reduces irritation.
Cleansing Masks/Gel Masks: Helps cleanse, softens cuticles, and enhances a refreshing feeling.
Hair Care Products: Adjusts pH, chelates metals, improves hair cuticles, and increases smoothness.
2. Iron Ion Determination (Most Mainstream) Fe3+
Spectrophotometric Colorimetric Method
Forms a stable purple-red water-soluble complex under acidic conditions. High sensitivity and stable color development.
5-Sulfosalicylic acid Applications: Detection of iron content in water quality, water samples, soil, ores, alloys, food, and pharmaceutical solutions.
Can distinguish between ferric and non-ferrous iron; measures only ferric iron without oxidation.
3. Protein Determination
Sulfosalicylic Acid Method for Protein Detection
Principle: Strong acid environment denatures and coagulates proteins, producing turbidity.
Applications: Qualitative, semi-quantitative, and turbidimetric determination of urine protein, cerebrospinal fluid protein, biological agents, and serum protein. Routine method in clinical laboratories and biochemistry labs.
Metal Ion Colorimetric and Quantitative Methods Determines:
Forms different colored complexes at different pH levels, used in spectrophotometric analysis.
Uses: As a metal indicator in complexometric titration.
4. Ion Masking Agent
Masks interfering ions during analysis, eliminating interference from coexisting ions and improving detection accuracy.
Acidity Adjustment and Buffer Reagents
Being strongly acidic, it is used to prepare acidic colorimetric solutions and standard buffer systems for analysis, controlling the pH value of the detection system.
Other Analytical Scenarios
Indirect colorimetric determination of nitrates and nitrites.
Analysis of inorganic minerals, building materials, and metallurgical raw materials.
Water quality monitoring: analysis of impurities and ions in wastewater, drinking water, and industrial circulating water.
Detection of drug purity and impurities in active pharmaceutical ingredients.
Ⅲ .Advantages of 5-Sulfosalicylic acid dihydrate cas no 5965-83-3 :
1. Excellent Water Solubility: Purely water-soluble, requiring no organic solvents such as ethanol, simple preparation, and no solvent interference.
Wide Acidity Range: Stable color development in strong to weak acidic environments, resistant to strong acids; sample acid leachates can be directly measured, and pH adjustment is simple.
2. Strong Anti-interference Ability: High tolerance to common anions and cations; can also be used as a masking agent to shield interfering ions such as aluminum and chromium; simple pretreatment.
3. Moderate Sensitivity and Good Reproducibility: Wide linear range, suitable for macro and semi-micro iron determination; stable data in batch detection.
4. Multi-purpose: Can be used as an iron colorimetric reagent, as well as for measuring titanium, aluminum, rare earth metals, proteins, adjusting acidity, and acting as a masking agent.
5. Low Cost and Availability: Inexpensive and widely available, suitable for large-scale routine testing in industrial and mining applications, environmental applications, and water quality.
Higher Safety: Low toxicity and low irritation; more environmentally friendly than thiocyanate, bipyridine, and aniline colorimetric reagents; waste liquid is easy to treat.
6. Good compatibility: It has good compatibility with common buffer solutions, salts, and sample matrices, and is not prone to turbidity or precipitation.
Ⅴ. 5-Sulfosalicylic acid dihydrate cas no 5965-83-3 Conclusion
5-Sulfosalicylic acid dihydrate is a functional molecule that combines strong acidity with complexing ability, playing an indispensable role in many industrial and scientific research fields.
