Other Names:Tris Base
MF:C4H11NO3
EINECS No.:201-064-4
Product name:Tris Base
CAS:77-86-1
What is of TROMETAMOL with cas 77-86-1?
Tris, or tris(hydroxymethyl)aminomethane, or known during medical use as tromethamine or THAM, is an organic compound with the formula (HOCH2)3CNH2. It is extensively used in biochemistry and molecular biology as a component of buffer solutions such as in TAE and TBE buffers, especially for solutions of nucleic acids. It contains a primary amine and thus undergoes the reactions associated with typical amines, e.g. condensations with aldehydes. Tris also complexes with metal ions in solution. In medicine, tromethamine is occasionally used as a drug, given in intensive care for its properties as a buffer for the treatment of severe metabolic acidosis in specific circumstances. Some medications are formulated as the “tromethamine salt” including hemabate (carboprost as trometamol salt), and “ketorolac trometamol”.
Specification
Item
|
Specifications
|
Results
|
Content
|
99.5%—101.0%
|
100.34%
|
Moisture
(by karl fischer) |
≤0.3%
|
0.19%
|
Insolubles
|
≤0.005%
|
0.00%
|
PH(5%)
|
10.0-11.5
|
10.65
|
UV Absorbance
(290nm,40%) |
≤0.2
|
0.050
|
UV Absorbance
(400nm 40%) |
≤0.2
|
0.011
|
Heavy metals(as pb)
|
≤5ppm
|
<5ppm
|
Fe
|
≤5ppm
|
<5ppm
|
Cl
|
≤3ppm
|
<5ppm
|
Solubility (1.0M solution in water)
|
Immediately soluble yielding a clear haze-free solution free of particulates
|
|
Residue on ignition
|
≤0.05%
|
0.00%
|
Melting point(℃)
|
168.0-172.0
|
171.5-171.9
|
Appearance
|
White crystal powder
|
|
Conclusion
|
The results conforms with Enterprise standards
|
Application
In the synthesis of surface-active agents, vulcanization accelerators, pharmaceuticals. As emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, leather dressings, textile specialties, polishes, cleaning Compounds, so-called soluble oils. Absorbent for acidic gases. Biological buffer.
Packing
25kgs/drum, 9tons/20’container