Ethyl L-pyroglutamate CAS 7149-65-7

CAS:7149-65-7
Molecular Formula:C7H11NO3
Molecular Weight:157.17
EINECS:230-480-9

Synonyms:ETHYL L-PYROGLUTAMATE; ETHYL (S)-PYROGLUTAMATE; ETHYL (S)-2-PYRROLIDINONE-5-CARBOXYLATE; ETHYL (S)-(+)-2-PYRROLIDONE-5-CARBOXYLATE; ETHYL (S)-2-PYRROLIDONE-5-CARBOXYLATE; H-PYR-OET; ethyl 5-oxo-L-prolinate; (S)-(+)-5-Ethylcarboxyl-2-pyrrolidinone

What is Ethyl L-pyroglutamate CAS 7149-65-7？

Ethyl L-pyroglutamate is a low melting point solid with a white to creamy color. It is a non natural amino acid derivative that has been used for protein modification in bacteria, yeast, and mammalian cells. It has applications in basic research, drug development, biotechnology, and other fields, and is widely used for detecting protein structural changes, drug coupling, biosensors, and other applications.

Specification

Item	Specification
Storage conditions	Keep in dark place
Density	1.2483 (rough estimate)
Melting point	54-56 °C
pKa	14.78±0.40(Predicted)
MW	157.17
optical activity	[α]19/D +3.3°, c = 10 in ethanol

Application

Ethyl L-pyroglutamate can be used as a pharmaceutical active molecule and organic synthesis intermediate, such as for the synthesis of biologically active molecule HIV integrase inhibitors. In synthetic conversion, the nitrogen atom in the amide group can be coupled with iodobenzene, or the hydrogen on the nitrogen atom can be converted to a chlorine atom. In addition, ester groups can be converted into amide products through aminoester exchange reactions.