1.Quick details of Clemastinefumarate with CAS 14976-57-9
- CAS No.:196194-58-8 147118-30-7 2611-67-8
Other Names:141761-83-3 1222-05-5 79673-53-3
Melting point 158-162°C
alpha D21 +16.9° (methanol)
Boiling point 154°C (rough estimate)
density 1.0247 (rough estimate)
refractive index 1.5790 (estimate) - MF: C25H30ClNO5
storage temp. 2-8°C
solubility DMSO: soluble5mg/mL (clear solution; warmed)
form powder
color white to beige
2.Description of Clemastinefumarate with CAS 14976-57-9
| Product Name: | Clemastine fumarate |
| Synonyms: | CLEMASTINE FUMARATE;CLEMASTINE FUMARATE SALT;(+)-2-(2-((p-chloro-alpha-methyl-alpha-phenylbenzyl)oxy)ethyl)-1-methylpyrro;(+)-2-(2-((p-chloro-alpha-methyl-alpha-phenylbenzyl)oxy)ethyl)-1-methylpyrroli;(+)-lfumarate(1:1);1-methyl-2-(2-(methyl-p-chlorodiphenylmethyloxy)ethyl)pyrrolidine;(2R)-2-[2-[(1R)-1-(4-CHLOROPHENYLETHOXY)]ETHYL]-1-METHYL-2-PYRROLIDINE FUMARATE;2-(2-(1-(4-chlorophenyl)-1-phenylethoxy)ethyl)-1-methylpyrrolidine |
| CAS: | 14976-57-9 |
| MF: | C25H30ClNO5 |
| MW: | 459.96 |
| EINECS: | 239-055-2 |
| Product Categories: | antianaphylaxis;TAVIST;Histaminergics;Antagonists;Neurotransmitters;Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol File: | 14976-57-9.mol |
3.Application
Clemastine fumarate is a selective histamine H1 receptor antagonist (Ki = 0.26 nM) that also displays high affinity for muscarinic receptors (Ki = 16 nM). It has also recently been identified as a positive allosteric modulator of P2X7 receptor signaling. Clemastine fumarate has long been used to inhibit histamine-induced bronchoconstriction in asthma and airway hyperresponsive studies.
4.Packing
25kgs/drum,9tons/20’container
25kgs/bag,20tons/20’container
