CROSCARMELLOSE SODIUM CAS 74811-65-7 powder

Croscarmellose Sodium CAS 74811-65-7 - Image 2

Croscarmellose Sodium CAS 74811-65-7 - Image 3

Croscarmellose Sodium CAS 74811-65-7 - Image 4

Croscarmellose Sodium CAS 74811-65-7

CAS:74811-65-7
Molecular Weight :0
EINECS：1312995-182-4
Storage Period :2 years
Synonyms:Sodiumcroscarmellose; CROSCARMELLOSE SODIUM; MODIFIED CELLULOSE GUM; Crosscarmelosesodium; Croscarmellose natrium; Cross-linked carboxymethylcellulose sodium;

What is Croscarmellose Sodium CAS 74811-65-7？

Croscarmellose Sodium is a white to milky white, fine dispersed, almost odorless and tasteless hygroscopic powder. It is insoluble in water and common solvents, and has strong hydrophobicity and high hygroscopicity, swelling upon contact with water. Cross-linked sodium carboxymethyl cellulose can cause the tablet to disintegrate rapidly, increase the dissolution of the drug and improve its bioavailability.

Croscarmellose Sodium is a cross-linked sodium carboxymethyl cellulose widely used as a super-disintegrant in pharmaceutical tablets and capsules. With exceptional swelling properties and rapid water-wicking capability, it ensures fast tablet disintegration and improved bioavailability. It is suitable for both direct compression and wet granulation processes.

Especificação

ITEM	PADRÃO
Identificação	A. The Croscarmellose Sodium absorbs the methylene blue and settles as a blue, fibrous mass, A. The Croscarmellose Sodium absorbs the methylene blue and settles as a blue, fibrous mass, C. A portion of the mixture of Croscarmellose Sodium with
pH	5.0~7.0
Settling Volume	The volume of the settled mass is 10.0~30.0 mL
Degree of Substitution	The degree of substitution is 0.60~0.85 on the dried basis.
Sodium Cholride and Sodium Glycolate	The sum of the percentages of sodium chloride and sodium glycolate is NMT 0.5%.
Content of Water-Soluble Material	NMT 10.0%
Perda por Secagem	NMT 10.0%
Resíduo de Ignição	14.0%~28.0%
Microbial Enumeration Tests and Tests For	The total aerobie microbial count does not exceed 1000 cfu/g
Specified Microorganisms	It meets the requirements of the test for absence of Escherichia

Croscarmellose Sodium Uses

1. Pharmaceutical Industry

Croscarmellose Sodium is one of the most widely used super-disintegrants in oral tablets and capsules.

It offers the key advantage of rapid water absorption and swelling without forming a gel barrier, ensuring fast disintegration and improving drug release and bioavailability.

This feature makes it essential in immediate-release formulations, enhancing patient compliance and therapeutic efficiency.

Key Croscarmellose Sodium Benefits in Pharma:

Speeds up tablet disintegration and dissolution
Enhances active ingredient bioavailability
Suitable for both direct compression and wet granulation
Consistent performance at low inclusion levels

2. Food Industry

As a food-grade auxiliary material complying with China GB 2760 and U.S. FDA GRAS standards, Croscarmellose Sodium functions as a:

Thickener
Stabilizer
Texture enhancer

It improves food texture, mouthfeel, and product stability in bakery items, beverages, and health supplements.

3. Daily Chemical & Personal Care Products

Toothpaste Applications

When added at 0.5%–1.5%, Croscarmellose Sodium acts as an auxiliary abrasive and viscosity enhancer.
By absorbing water and expanding, it increases the viscosity, elasticity, and smoothness of toothpaste, while helping to gently remove surface stains without scratching enamel.
It also has excellent compatibility with fluoride compounds and surfactants, ensuring stable fluoride release.

Skin Care Products

At 0.1%–0.3% in lotions, masks, and moisturizing products, Croscarmellose Sodium serves as a moisturizing stabilizer.
It absorbs moisture from the air, prolongs skin hydration, and provides a light, non-greasy feel, improving product texture and application performance.

Croscarmellose Sodium Benefits

Croscarmellose Sodium is recognized for its multi-functionality, excellent compatibility, and high safety, making it a truly universal excipient widely used across the pharmaceutical, food, and personal care industries. In oral solid dosage forms, it plays a pivotal role as a core disintegrant, significantly improving tablet disintegration and drug dissolution efficiency, thereby enhancing bioavailability and patient compliance. Driven by advances in the pharmaceutical and food sectors, the global demand for high-performance excipients like Croscarmellose Sodium continues to rise steadily.