p-Toluenesulfonyl Isocyanate CAS 4083-64-1

what is p-Toluenesulfonyl Isocyanate CAS 4083-64-1

p-Toluenesulfonyl Isocyanate (CAS 4083-64-1), also known as toluene-4-sulfonyl-isocyanate or p-tosyl isocyanate, is an important organic intermediate widely used in the synthesis of pharmaceuticals, agrochemicals, and specialty polymers. This compound contains both an isocyanate group (-NCO) and a sulfonyl group (-SO₂-), providing strong reactivity and selectivity in organic reactions.

Its stable reactivity makes it valuable for introducing sulfonyl and carbamoyl functionalities into complex molecules. Because of its versatility and high purity, p-toluenesulfonyl isocyanate CAS 4083-64-1 is commonly used in industrial-scale chemical production.

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应用程序

P-toluenesulfonyl Isocyanate (‌PTSI) ‌ is also used as an intermediate in medicine or pesticide, and as a dehydrating agent in solvent, filler, pigment, etc., and is effectively applied in wet-cured one-component and conventional two-component polyurethane paint systems. ‌PTSI is widely used in chemical products as a dehydrating agent and also as a stabilizer in purified bisisocyanates to prevent their deterioration or discoloration.

1. Pharmaceutical Intermediates
   p-Toluenesulfonyl isocyanate is frequently used to produce urea and carbamate derivatives in drug synthesis. It acts as a reagent for modifying amines and alcohols, allowing the creation of biologically active compounds and protective groups in organic chemistry.

2. Polymer and Coating Chemistry
   In polymer chemistry, toluene-4-sulfonyl-isocyanate serves as a crosslinking agent and reactive modifier for polyurethane and polyurea materials, improving mechanical strength and chemical resistance.

3. Agrochemical Production
   p-Tosyl isocyanate participates in the synthesis of active pesticide intermediates, herbicides, and fungicides. Its high reactivity helps form stable sulfonyl-urea structures, essential in modern crop protection formulations.

4. Analytical Reagents & Chemical Synthesis
   Due to its strong electrophilic property, p-toluenesulfonyl isocyanate 4083-64-1 is used as a derivatization agent for amines, alcohols, and phenols in analytical chemistry and high-performance synthesis reactions.

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