EDTA 2NA vs EDTA 4NA: What’s the Difference？

When it comes to chelating agents, EDTA 2NA and EDTA 4NA are two of the most widely used forms in industrial, cosmetic, and cleaning formulations. Both are salts of ethylenediaminetetraacetic acid (EDTA), but they differ in their chemical composition, pH behavior, and applications. Understanding these differences helps formulators and manufacturers choose the right grade for their needs.

As a professional EDTA 2NA supplier and EDTA 4NA supplier, we’ll help you clearly understand how to select between the two.

I. What is EDTA 2NA (CAS 6381-92-6)?

EDTA 2NA, also known as EDTA Disodium Salt Dihydrate (CAS number 6381-92-6), is a white crystalline powder widely used for its excellent chelating ability. It binds with metal ions such as calcium, magnesium, and iron, effectively preventing metal-catalyzed reactions and discoloration in various formulations.

1. Key Properties

Chemical name: Ethylenediaminetetraacetic acid disodium salt dihydrate

CAS Không: 6381-92-6

Xuất hiện: Bột trắng

Hòa tan: Dễ dàng, hòa tan trong nước

pH (1% solution): Approximately 4.0–6.0

Công thức phân tử: C₁₀H₁₄N₂Na₂O₈·2H₂O

2. Common Applications of EDTA-2NA

Skincare and Personal Care Products – In cosmetics and shampoos, EDTA-2NA skincare grade helps stabilize formulations by binding with metal ions that can cause oxidation or color change.

Cleaning and Detergent Industry – Improves cleaning efficiency by softening water and enhancing surfactant performance.

Pharmaceuticals and Food Processing – Acts as a preservative enhancer and stabilizer.

Water Treatment – Used for removing heavy metal ions from solutions.

If you are looking for EDTA disodium salt dihydrate bulk supply, our factory provides consistent quality, competitive EDTA 2NA price, and customized packaging.

II. What is EDTA 4NA (CAS 13235-36-4)?

EDTA 4NA, also known as Tetrasodium EDTA Tetrahydrate (CAS 13235-36-4), is another salt form of ethylenediaminetetraacetic acid. It has higher alkalinity and solubility compared to EDTA 2NA, making it particularly suitable for formulations that require a higher pH range.

1. Key Properties

Chemical name: Ethylenediaminetetraacetic acid tetrasodium salt tetrahydrate

CAS Không: 13235-36-4

Xuất hiện: White crystalline powder or granule

pH (1% solution): 10.0–11.5

Hòa tan: Very soluble in water

2. Common Applications

Household and Industrial Cleaners – Excellent for alkaline formulations such as laundry detergents, degreasers, and dishwashing liquids.

Textile and Paper Industry – Used to remove metal ions that interfere with dyeing or bleaching.

Water Treatment – For controlling metal ion content in industrial water systems.

III. EDTA 2NA vs EDTA 4NA: Main Differences

Comparison	EDTA 2NA	EDTA 4NA
Full Name	EDTA Disodium Salt Dihydrate	EDTA Tetrasodium Salt Tetrahydrate
CAS Số	6381-92-6	13235-36-4
pH Range (1% Solution)	4.0–6.0	10.0–11.5
Hòa tan	Good	Tuyệt vời
Best for	Neutral or slightly acidic formulations (e.g., skincare)	Alkaline formulations (e.g., cleaners, detergents)
Typical Uses	Cosmetics, personal care, pharmaceuticals	Industrial cleaners, water treatment, detergents
Ionic Form	Partial neutralization (two sodium ions)	Fully neutralized (four sodium ions)

• EDTA 2NAis preferred for personal care and cosmetic products because of its mild pH and compatibility with other ingredients.
• EDTA 4NAis better suited for alkaline industrial applications like detergents and cleaning agents.

IV. How to Choose Between EDTA 2NA and EDTA 4NA

1. Check your formulation’s pH

For acidic to neutral systems (pH 4–7) → use EDTA-2NA.

For alkaline systems (pH 9–11) → use EDTA-4NA.

2. Consider solubility and compatibility

Both are water-soluble, but EDTA 4NA dissolves faster and more completely in high-pH formulations.

3. Evaluate the final application

For cosmetic and skincare products, EDTA-2NA improves stability and prevents oxidation.

For industrial detergents or water treatment, EDTA-4NA provides superior metal chelation under alkaline conditions.

V. EDTA 2NA Price and Supply Information

We provide EDTA 2NA and EDTA 4NA in bulk quantities, ensuring consistent quality, purity, and competitive pricing.

Packaging: 25kg bags or customized options

Grade: Industrial, Cosmetic, and Technical

Supply form: White crystalline powder

Origin: China

As a trusted EDTA 2NA supplier, we offer technical support and product samples for testing. Whether you need EDTA disodium salt dihydrate bulk or tetrasodium EDTA tetrahydrate, we can provide reliable supply to meet your production needs.

VI. Kết luận

Both EDTA 2NA (CAS 6381-92-6) and EDTA 4NA (CAS 13235-36-4) are valuable chelating agents, but their performance depends on the formulation environment. Choose EDTA-2NA for cosmetics, skincare, and neutral pH systems.Choose EDTA-4NA for alkaline cleaners, detergents, and water treatment.As a professional manufacturer and exporter, we supply both EDTA Disodium Salt Dihydrate and Ethylenediaminetetraacetic acid Tetrasodium Salt, ensuring you always get the right grade for your specific application.