Ethyl Nicotinate CAS 614-18-6

What is Ethyl nicotinate CAS 614-18-6？

Ethyl Nicotinate (CAS 614-18-6), also known as ethyl pyridine-3-carboxylate or nicotinic acid ethyl ester, is an ester derivative of niacin (Vitamin B3). It appears as a colorless to pale yellow transparent liquid with a faint fruity and slightly pungent aroma. Owing to its exceptional skin-penetrating ability and vasodilating properties, Ethyl Nicotinate is widely used in cosmetics, personal care formulations, pharmaceuticals, and sports-care products.

This compound is insoluble in water, yet highly miscible with most organic solvents such as ethanol, ether, and chloroform, making it highly adaptable to modern formulation systems. By rapidly improving micro-circulation and warm sensation upon topical application, it is frequently incorporated into slimming creams, massage gels, anti-cellulite lotions, and muscle-warming balms.

Beyond cosmetics, Ethyl Nicotinate also serves as a penetration enhancer and counter-irritant in topical pharmaceutical preparations. Its ability to stimulate local blood flow supports enhanced ingredient delivery, increased nutrient absorption, and faster metabolism activation, making it a valuable functional ingredient across multiple industries.

Specifica

Ethyl Nicotinate Uses

1. Pharmaceutical & Medical Field – Vitamin Support and Local Action

Ethyl Nicotinate plays an important role in the pharmaceutical industry due to its dual functionality. As a vitamin B3 (niacin) derivative, it provides mild and sustained vitamin supplementation, helping support energy metabolism and cellular function.

Additionally, its strong topical penetration and vasodilating properties make it suitable for local treatment applications, including circulation-boosting creams, warming medicated ointments, and transdermal delivery systems.

With its targeted delivery and gentle activity, Ethyl Nicotinate is valued in functional pharmaceutical and cosmeceutical products designed for improved micro-circulation and nutrient supply.

2. Personal Care & Daily Chemical Industry – Skin & Hair Vitality

Thanks to its mild activity, excellent skin permeability, and micro-circulation activation, Ethyl Nicotinate is widely used in functional skincare and hair care formulas. It helps warm the skin, enhance nutrient absorption, and support scalp vitality.

Ethyl Nicotinate improves blood flow, ingredient delivery, and skin metabolism, making it a popular active ingredient in premium beauty formulations.

3. Food & Feed Industry – Nutritional Fortification & Flavor Enhancement

As a niacin derivative, Ethyl Nicotinate can be used as a vitamin B3 fortifier to enhance nutritional value in food and feed products. It offers the advantage of reducing the sour taste of niacin, making it suitable for mild-flavor and infant formulations.

Common food ethyl nicotinate uses:

• Bakery products (bread, biscuits)

• Sports beverages & nutritional drinks

• Infant and toddler complementary foods

Typical addition rate: 0.01% – 0.05%, depending on formulation needs.

Key Features & Benefits of Ethyl Nicotinate

1. Gentle and Suitable for Sensitive Skin

Ethyl Nicotinate offers a milder, low-irritation profile compared with niacin, greatly reducing the risk of redness or flushing. Its gentle action makes it ideal for sensitive-skin formulations, including oral skin-health supplements and topical vitamin care products designed for delicate skin.

2. High Bioavailability and Efficient Conversion

With excellent skin and mucosal penetration, Ethyl Nicotinate is rapidly absorbed and enzymatically converted into active niacin in the body. This delivers efficient circulation-boosting and cell-energizing effects superior to traditional niacin gels and allows enhanced performance in hair-care and anti-hair-loss products.

3. Excellent Compatibility in Formulations

Ethyl Nicotinate dissolves easily in both water- and oil-based systems, demonstrating strong compatibility with surfactants, preservatives, vitamins, and functional actives. It can be seamlessly incorporated into multi-functional skincare products, nutritional supplements, and fortified food systems without destabilizing formulas.

4. Safe for Oral and Topical Use

With a low toxicity profile and wide regulatory recognition, Ethyl Nicotinate is proven safe for oral supplements and topical applications. Its safety record supports use across diverse populations—including infants, the elderly, and sensitive users—in infant food, healthcare products, and pharmaceutical preparations.

Imballaggio

200kg/ drum